Yi’anping® is the commercial brand name of Ambroxol Hydrochloride Solution for Inhalation, a mucolytic agent for aerosol inhalation administration. It acts on airway mucus glands to reduce viscous mucus secretion, dilute thick sputum, activate ciliary movement of respiratory epithelium, accelerate sputum excretion and relieve cough and expectoration symptoms.
Main Indications
Expectorant treatment for acute and chronic respiratory diseases accompanied by abnormal mucus secretion and poor sputum excretion;
Adjuvant inhalation therapy for bronchitis, pneumonia, bronchial asthma, bronchiectasis and chronic obstructive pulmonary disease to improve sputum clearance.
Clinical Research
Multicenter randomized controlled clinical trials verified that inhaled ambroxol achieves rapid local drug concentration in the respiratory tract, showing faster sputum dilution and cough relief than oral ambroxol preparations;
Domestic clinical trials in pediatric and adult patients confirmed good local tolerance during atomized inhalation, with low systemic drug absorption and fewer systemic adverse reactions;
Real-world clinical observation proved that combined use with bronchodilators can further improve ventilation and sputum drainage in patients with obstructive airway disease.
Common Side Effects
Serious adverse reactions: Severe hypersensitivity, anaphylactoid reaction, severe bronchospasm induced by inhalation stimulation (rare but severe);
Common mild adverse reactions: Throat irritation, dry mouth, nausea, vomiting, abdominal discomfort, occasional skin rash and itching.
Approval Status in China
Original drug Yi’anping® (Ambroxol Hydrochloride Solution for Inhalation) was officially approved for marketing in China with the specification of 2ml:15mg, 24 sticks per box. It is currently a prescription drug included in China’s category B medical insurance.
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