Eylea® is the commercial brand name of Aflibercept Intravitreal Injection, a recombinant fusion protein anti-VEGF drug developed by Bayer. It binds vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), inhibits pathological retinal neovascularization and vascular leakage, alleviates retinal edema and visual damage via intravitreal injection.
Main Indications
Treatment of neovascular age-related macular degeneration (nAMD) in adults;
Treatment of diabetic macular edema (DME) secondary to diabetic retinopathy in adults;
Treatment of macular edema caused by retinal vein occlusion (RVO);
Treatment of myopic choroidal neovascularization (mCNV) in adult patients.
Clinical Research
Global multicenter phase III pivotal trials demonstrated that aflibercept exerts durable anti-VEGF activity, which can prolong the injection interval while maintaining stable visual efficacy compared with short-acting anti-VEGF drugs;
Registration clinical trials involving Chinese subjects verified obvious improvement in best corrected visual acuity and reduction of macular retinal thickness, with consistent efficacy and safety profiles versus global trial cohorts;
Long-term real-world clinical follow-up proved that it can cut down the annual injection times for patients with chronic retinal vascular lesions and ease long-term treatment pressure.
Common Side Effects
Severe adverse reactions: Intraocular endophthalmitis, retinal detachment, traumatic cataract, massive intraocular hemorrhage, systemic hypersensitivity reaction (rare but severe);
Common mild adverse reactions: Conjunctival hemorrhage, ocular pain, transient blurred vision, vitreous opacities, temporary intraocular pressure elevation, local eye irritation at the injection site.
Approval Status in China
Eylea® (Aflibercept Intravitreal Injection, 114.3 mg/mL) was granted marketing approval in China in 2018. It is a prescription ophthalmic biologic agent covered by Class B National Medical Insurance.
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