Velphoro® (Chinese brand name: Weifurui®) is the commercial brand name of Sucroferric Oxyhydroxide Chewable Tablets, a non-calcium oral phosphate binder developed by Fresenius Medical Care. It combines with dietary phosphate within the gastrointestinal tract to form insoluble phosphate complexes excreted in feces, reducing intestinal phosphorus absorption and decreasing blood phosphorus levels to treat hyperphosphatemia in chronic kidney disease patients.
Main Indications
Control of serum phosphorus levels in adult chronic kidney disease (CKD) patients undergoing hemodialysis (HD) or peritoneal dialysis (PD);
Control of elevated serum phosphorus in adolescents aged 12 years and older with CKD stage 4–5 or pediatric CKD patients receiving dialysis.
Clinical Research
Global multicenter phase III pivotal trials demonstrated that sucroferric oxyhydroxide achieves non-inferior phosphorus-lowering efficacy compared with sevelamer carbonate, requiring fewer daily tablets to improve medication compliance while maintaining long-term stable serum phosphorus control;
Registration clinical trials including Chinese adult and adolescent CKD patients confirmed rapid phosphorus-lowering onset, durable efficacy and comparable safety profiles consistent with global trial subjects;
Long-term extension clinical trials verified sustained phosphorus reduction over one year, with gastrointestinal adverse events mainly appearing in the initial treatment phase and gradually mitigating with continued use, with no significant impact on systemic iron metabolism or fat-soluble vitamin absorption.
Common Side Effects
Severe adverse reactions: Rare hypersensitivity reactions, severe gastrointestinal obstruction;
Common mild adverse reactions: Black discoloration of stool, diarrhea, nausea, vomiting, constipation, flatulence, abdominal discomfort.
Approval Status in China
Velphoro® (Sucroferric Oxyhydroxide Chewable Tablets, specification: 0.5g calculated by iron per tablet, original imported drug) was approved for marketing in China for hyperphosphatemia management in dialysis-dependent adult CKD patients and adolescent CKD patients over 12 years old, providing a high-adherence non-calcium phosphate-binding therapeutic option for Chinese nephropathy patients.
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