Yilian® is the commercial brand name of Ilaprazole Sodium for Injection, a proton pump inhibitor developed by Livzon. It inhibits gastric H⁺/K⁺‑ATPase, suppresses gastric acid secretion for long duration and elevates intragastric pH.
Main Indications
Treatment of duodenal ulcer, gastric ulcer, acute upper gastrointestinal bleeding.
Clinical Research
Phase III clinical trial demonstrated that intravenous ilaprazole sodium achieves rapid and sustained acid suppression, with non-inferior hemostatic efficacy compared with injectable omeprazole in patients with acute upper gastrointestinal bleeding;
The study showed good tolerability and low incidence of adverse events in Chinese population;
Pharmacodynamic studies confirmed its long half-life and strong acid inhibitory effect.
Common Side Effects
Severe but important risks: Severe hypersensitivity reactions, hepatic function impairment;
Common mild adverse reactions: Headache, dizziness, diarrhea, nausea, abdominal distension, elevated transaminases and injection site reactions.
Approval Status in China
Original drug Yilian® (Ilaprazole Sodium for Injection, specification:10mg per vial) was officially approved for marketing in China in 2021. It is currently a prescription injectable proton pump inhibitor.
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