Ruoxinlin® is the domestic brand name of Toludesvenlafaxine Hydrochloride Sustained-release Tablets, a novel serotonin-norepinephrine reuptake inhibitor. It blocks the reuptake of serotonin and norepinephrine to exert antidepressant effects.
Main Indications
For the treatment of major depressive disorder in adults.
Clinical Research
Phase III clinical studies showed that toludesvenlafaxine significantly reduces MADRS total scores compared with placebo at week 8. It demonstrates rapid onset of antidepressant action and a favourable tolerability profile. The sustained-release formulation helps maintain stable plasma drug concentrations.
Common Side Effects
Nausea, dry mouth, dizziness;
Other common reactions: insomnia, somnolence, decreased appetite, sweating. Rare serious adverse events include elevated blood pressure, serotonin syndrome and suicidal ideation.
Approval Status in China
Generic drug Ruoxinlin® (Toludesvenlafaxine Hydrochloride Sustained-release Tablets) was officially approved for marketing in China in 2022, with the specification of 80mg per tablet. It is currently a prescription drug.
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