Vancocin® is the commercial brand name of Vancomycin Hydrochloride Capsules, a glycopeptide antibacterial agent. It inhibits bacterial cell wall synthesis and exerts bactericidal activity against gram-positive pathogens.
Main Indications
For the treatment of pseudomembranous colitis caused by Clostridioides difficile; also used for staphylococcal enterocolitis. Oral vancomycin is not effective for systemic infections.
Clinical Research
Clinical trials demonstrated that oral vancomycin achieves high drug concentration within the gastrointestinal tract. It is superior to metronidazole for severe or recurrent C. difficile infection, with high clinical response rates for first-episode infection. Systemic absorption is minimal after oral administration.
Common Side Effects
Nausea, abdominal pain, diarrhoea;
Other common reactions: dysgeusia. Rare serious adverse events include hypersensitivity reactions. Ototoxicity and nephrotoxicity rarely occur with oral use due to low systemic absorption.
Approval Status in China
Generic drug Wantuoxin® (Vancomycin Hydrochloride Capsules) was officially approved for marketing in China in 2024, with the specification of 0.125g per capsule. It is currently a prescription drug.
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