Intuniv® is the original reference brand name, while the marketed domestic generic product in China is Le’erjing®. It is a selective alpha‑2A adrenergic receptor agonist. It acts on prefrontal cortex alpha‑2A receptors to regulate noradrenergic signaling and improve attention and impulse control.
Main Indications
For the treatment of attention deficit hyperactivity disorder (ADHD) in children aged 6 years and older.
Clinical Research
Clinical trials showed that this domestic sustained-release guanfacine significantly reduces core ADHD symptoms including inattention, hyperactivity and impulsivity in pediatric patients. It demonstrates sustained efficacy with once-daily administration. The safety profile is acceptable when the dose is gradually titrated.
Common Side Effects
Systemic reactions: somnolence, fatigue;
Common mild adverse reactions: dry mouth, headache, decreased appetite. Rare serious adverse events: hypotension, bradycardia.
Approval Status in China
This domestic generic drug, marketed under brand name Le’erjing® (reference brand name Intuniv®), was officially approved for marketing in China in 2025, with the specification of 1mg, 2mg. It is currently a prescription neuropsychiatric drug.
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