Azopt® is the commercial brand name of Brinzolamide Ophthalmic Suspension, a topical ocular carbonic anhydrase inhibitor developed by Alcon (Novartis Group). It inhibits carbonic anhydrase isoenzyme in the ciliary body, reduces aqueous humor secretion, and lowers intraocular pressure to control glaucoma progression.
Main Indications
Reduction of elevated intraocular pressure in patients with ocular hypertension;
Reduction of elevated intraocular pressure in patients with open-angle glaucoma;
Monotherapy for patients intolerant or contraindicated to beta-blocker eye drops, or combination adjuvant therapy with beta-blockers for intraocular pressure control.
Clinical Research
Global multicenter phase III pivotal trials proved that 1% brinzolamide ophthalmic suspension achieves stable intraocular pressure reduction for 24 hours with twice or three times daily topical administration;
Combination clinical trials confirmed synergistic intraocular pressure-lowering effect when used together with timolol maleate eye drops, improving target intraocular pressure attainment for refractory glaucoma patients;
Domestic multicenter registration trials in Chinese glaucoma patients verified consistent efficacy and local tolerability compared with overseas clinical trial data.
Common Side Effects
Severe adverse reactions: Systemic sulfonamide hypersensitivity, severe ocular allergic reaction, irregular cardiac rhythm, renal function abnormality (rare but severe);
Common mild adverse reactions: Dysgeusia (bitter taste after instillation), transient blurred vision, conjunctival hyperemia, ocular foreign body sensation, headache, nasopharyngitis, dry eye discomfort.
Approval Status in China
Original drug Azopt® (Brinzolamide Ophthalmic Suspension, specification: 5mL:50mg) was officially approved for marketing in China in 2014. It is currently a prescription ophthalmic drug included in China’s category B medical insurance.
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