Fosrenol® (Chinese brand name: Fusilinuo®) is the commercial brand name of Lanthanum Carbonate Chewable Tablets, a non-calcium, non-aluminum oral phosphate binder developed by Shire Pharmaceuticals. It binds phosphate from food in the gastrointestinal tract to form insoluble lanthanum phosphate compounds that are excreted via feces, lowering serum phosphorus to treat hyperphosphatemia in chronic kidney disease patients.
Main Indications
Treatment of hyperphosphatemia in adult patients with chronic kidney disease receiving dialysis therapy;
Control of elevated serum phosphate for patients with renal osteodystrophy caused by long-term high phosphorus levels.
Clinical Research
Global multicenter phase III pivotal trials demonstrated that lanthanum carbonate delivers powerful phosphate-binding capacity with minimal systemic absorption, avoiding hypercalcemia and aluminum accumulation linked to traditional phosphate binders and reducing vascular calcification risk;
Registration clinical trials enrolling Chinese dialysis patients confirmed stable phosphorus-lowering efficacy and consistent efficacy and safety outcomes compared with global study populations;
Long-term follow-up studies in Chinese nephrology wards proved its good long-term tolerability for maintenance phosphorus control in hemodialysis and peritoneal dialysis patients.
Common Side Effects
Severe adverse reactions: Rare intestinal obstruction, allergic reaction, abnormal lanthanum deposition in organs;
Common mild adverse reactions: Nausea, vomiting, constipation, diarrhea, stomach upset, dysgeusia.
Approval Status in China
Fosrenol® (Lanthanum Carbonate Chewable Tablets, specification: 500mg per tablet, Shire original imported drug) was approved for marketing in China in 2004. It is a prescription chewable phosphate-lowering drug for long-term management of hyperphosphatemia in dialysis patients.
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