Inspra® is the commercial brand name of Eplerenone Tablets, a selective aldosterone receptor antagonist. Limeitong is the Chinese pinyin brand name of the domestic generic version of eplerenone. It blocks mineralocorticoid receptors to reduce sodium and water retention and exert anti-fibrotic effects on myocardium.
Main Indications
Treatment of heart failure with reduced ejection fraction to reduce cardiovascular death and hospitalization risk in adult patients; treatment of hypertension.
Clinical Research
Large randomized clinical trials demonstrated that eplerenone added to standard heart failure therapy lowered the risk of cardiovascular mortality and readmission. It effectively reduces blood pressure with a lower incidence of gynecomastia compared with spironolactone.
Common Side Effects
Hyperkalemia, dizziness, elevated serum creatinine;
Other common reactions: diarrhea, nausea. Rare serious adverse events include severe hyperkalemia leading to arrhythmia.
Approval Status in China
Inspra® is the imported original drug. Limeitong is the domestic generic formulation of Eplerenone Tablets approved in China in 2023, with specifications including 25mg, 14 tablets per bottle. Both are prescription drugs.
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