Livtencity® is the commercial brand name of Maribavir Tablets. It is an oral benzimidazole antiviral agent that inhibits human cytomegalovirus (CMV) DNA synthesis by targeting viral UL97 kinase, exerting potent activity against CMV strains resistant to traditional ganciclovir and foscarnet.
Main Indications
Treatment of refractory or drug-resistant human cytomegalovirus (CMV) infection in adult transplant recipients.
Clinical Research
Global multicenter phase III pivotal trials fully validated its antiviral efficacy against drug-resistant CMV strains in transplant populations;
Head-to-head comparative registration trials confirmed higher CMV viral clearance rate and better oral tolerability versus traditional injectable anti-CMV therapies;
Long-term post-transplant cohort follow-up studies demonstrated sustained suppression of recurrent CMV viremia with once-daily oral administration;
Dose-finding research verified balanced antiviral activity and systemic safety of the 0.2g twice-daily regimen;
Chinese domestic registration trials confirmed favorable therapeutic effect and manageable adverse reaction spectrum for local solid organ and hematopoietic stem cell transplant patients.
Common Side Effects
Common mild adverse reactions: Taste disturbance, nausea, vomiting, diarrhea, fatigue and headache;
Laboratory abnormalities: Rare transient mild elevation of liver transaminases and serum lipid fluctuations;
Severe but uncommon risks: Severe gastrointestinal intolerance, severe hypersensitivity rash and clinically relevant neutropenia.
Approval Status in China
Original drug Livtencity® was officially approved for marketing in China in 2023, with the specification of 0.2g per tablet, 56 tablets per bottle, 1 bottle per box. It is currently a prescription antiviral drug included in China’s Category B medical insurance catalogue.
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