Lonasen® is the commercial brand name of Blonanserin Tablets, an oral atypical antipsychotic developed by Sumitomo Dainippon Pharma of Japan. It is a dual dopamine‑serotonin antagonist that blocks dopamine D2 and serotonin 5‑HT2A receptors, relieving both positive and negative psychotic symptoms of schizophrenia.
Main Indications
Treatment of adult patients with schizophrenia, including acute‑phase symptom control and long‑term maintenance therapy for relapse prevention.
Clinical Research
Global multicenter randomized controlled trials demonstrated that blonanserin effectively improves positive symptoms (hallucinations, delusions, thought disorder) and negative symptoms (apathy, social withdrawal, blunted affect) in schizophrenia patients;
Phase‑I bioequivalence trials conducted among healthy Chinese volunteers verified that imported blonanserin tablets are bioequivalent to the original reference drug with satisfactory safety performance;
Meta‑analysis of clinical studies showed blonanserin has relatively lower risks of significant weight gain and metabolic disturbance compared with many other atypical antipsychotic agents.
Common Side Effects
Extrapyramidal reactions: tremor, akathisia, parkinson‑like symptoms;
Frequent mild adverse reactions: somnolence, insomnia, dizziness, constipation;
Rare severe risks: QT‑interval prolongation, neuroleptic malignant syndrome, agranulocytosis. Mild‑to‑moderate weight gain and lipid changes may also occur.
Approval Status in China
Original drug Lonasen® (Blonanserin Tablets) obtained import drug license in February 2017 and was officially launched on the Chinese market in February 2018. It is a prescription drug.
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