How much does Repatha (Evolocumab Injection) Cost& price without insurance in China?
Repatha® is the commercial brand name of Evolocumab Injection, developed by Amgen Manufacturing Limited. It is a fully human monoclonal antibody targeting PCSK9; it blocks the binding between PCSK9 and hepatic LDL receptors to elevate LDL receptor quantity, significantly lowering circulating low-density lipoprotein cholesterol and reducing atherosclerotic cardiovascular risks.
Main Indications
Adjuvant lipid-lowering therapy combined with diet and statins for adults with primary hypercholesterolemia;
Reduction of major adverse cardiovascular events in adult patients with established atherosclerotic cardiovascular disease.
Clinical Research
Global multicenter pivotal trials fully validated its powerful long-term LDL-C lowering efficacy for hyperlipidemic populations;
Lipid management registration trials confirmed sustained profound cholesterol reduction for statin-intolerant or statin-inadequate responders;
Cardiovascular outcome observational studies demonstrated obvious decline in myocardial infarction, ischemic stroke and cardiovascular death risks;
Dosing cycle comparative research showed monthly or biweekly subcutaneous administration improves long-term patient compliance;
Long-term safety follow-up trials verified mild and controllable overall adverse reaction spectrum during chronic treatment.
Common Side Effects
Common mild adverse reactions: Injection site erythema, pruritus, headache, back pain and influenza-like symptoms;
Laboratory abnormalities: Rare transient mild elevation of liver transaminases;
Severe but uncommon risks: Severe systemic hypersensitivity, myalgia with elevated creatine kinase and thrombocytopenia.
Approval Status in China
Repatha® (specification 1mL:140mg per pre-filled pen, 1 pen per box) obtained marketing approval in China in 2018. It is a subcutaneous injectable prescription biologic lipid-lowering drug included in China’s Category B medical insurance catalogue.
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