Seroquel XR® is the commercial brand name of Quetiapine Fumarate Sustained-release Tablets, an atypical antipsychotic developed by AstraZeneca. It binds to multiple neurotransmitter receptors in the brain to regulate neural activity and relieve psychiatric symptoms.
Main Indications
Treatment of schizophrenia; treatment of bipolar disorder, including manic episodes and depressive episodes; maintenance treatment to prevent relapse of bipolar disorder; adjunctive treatment for major depressive disorder.
Clinical Research
Series of controlled clinical trials prove that quetiapine sustained-release formulation effectively improves positive and negative symptoms of schizophrenia. It demonstrates efficacy in both manic and depressive phases of bipolar disorder, and shows benefits for sleep disturbance accompanied with psychiatric disorders. The sustained-release formulation achieves stable drug concentration and improves patient medication adherence.
Common Side Effects
Somnolence, dizziness, dry mouth and weight gain are frequently reported adverse reactions. Other reactions include orthostatic hypotension, elevated serum prolactin, dyspepsia and fatigue.
Approval Status in China
Original drug Seroquel XR® (Quetiapine Fumarate Sustained-release Tablets) was officially approved for marketing in China in 2007. It is a prescription psychiatric medicine covered by China’s medical insurance.
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