YouShiying® is the commercial brand name of Fluocinolone Acetonide Intravitreal Implants, a long-term sustained-release intravitreal corticosteroid implant developed by EyePoint Pharmaceuticals and introduced by OcuMension. It continuously releases fluocinolone acetonide inside the vitreous body to inhibit intraocular inflammatory cascade, relieve posterior segment intraocular inflammation and macular edema via long-duration local drug delivery.
Main Indications
Treatment of chronic non-infectious uveitis involving the posterior segment of the eye in adult patients.
Clinical Research
Global multicenter Phase III pivotal clinical trials confirmed that single intravitreal implantation achieves continuous anti-inflammatory drug release for up to 36 months, markedly reduces uveitis recurrence frequency and lowers dependence on systemic or periocular glucocorticoids;
Registration clinical trials enrolling Chinese patients verified consistent long-term efficacy and safety profiles compared with global trial cohorts for Chinese chronic posterior uveitis patients;
Long-term observational follow-up studies demonstrated that one implantation effectively reduces repeated intraocular injection operations for refractory recurrent uveitis.
Common Side Effects
Severe adverse reactions: Elevated intraocular pressure requiring anti-glaucoma medication or surgical intervention, progressive cataract needing surgery, intraocular endophthalmitis, implant displacement (rare but severe);
Common mild adverse reactions: Conjunctival congestion, vitreous floaters, transient blurred vision, ocular foreign body sensation, subconjunctival hemorrhage at the implantation site.
Approval Status in China
Original drug YouShiying® (Fluocinolone Acetonide Intravitreal Implants, specification: 0.18mg per implant) was officially approved for marketing in China in June 2022. It is currently a prescription ophthalmic drug included in China’s category B medical insurance.
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