How much does Leqvio (Inclisiran Sodium Injection) Cost& price without insurance in China?
Leqvio® is the commercial brand name of Inclisiran Sodium Injection, developed by Novartis. It is a long-acting small interfering RNA therapeutic agent targeting PCSK9 synthesis. It inhibits hepatic PCSK9 production persistently, elevates low-density lipoprotein receptor levels on liver cells and achieves durable LDL-cholesterol reduction with twice-yearly subcutaneous dosing.
Main Indications
Adjunct lipid-lowering therapy combined with statins for adults with primary hypercholesterolemia to lower LDL-C;
Long-term secondary cardiovascular risk reduction in adult patients with established atherosclerotic cardiovascular disease.
Clinical Research
Global multicenter pivotal trials fully validated its semi-annual long-lasting lipid-lowering efficacy for hyperlipidemic patients;
Phase III registration trials confirmed stable sustained LDL-C reduction with only two maintenance injections per year;
Cardiovascular outcome observational studies demonstrated significant reduction of major adverse cardiovascular event risks;
Subcutaneous administration comparative research showed improved long-term medication adherence versus biweekly PCSK9 monoclonal antibodies;
Long-term safety follow-up trials verified mild injection-related reactions and controllable overall adverse reaction spectrum.
Common Side Effects
Common mild adverse reactions: Injection site pain, erythema, headache, back pain and arthralgia;
Laboratory abnormalities: Rare transient mild elevation of liver transaminases;
Severe but uncommon risks: Severe systemic hypersensitivity reactions, persistent myalgia and thrombocytopenia.
Approval Status in China
Leqvio® (specification 1.5ml:284mg per pre-filled syringe with needle safety device, 1 syringe per box) obtained marketing approval in China in 2023. It is a subcutaneous injectable prescription RNA lipid-regulating drug included in China’s Category B medical insurance catalogue.
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