How much does Sandostatin LAR (Octreotide Acetate Microspheres for Injection) Cost& price without insurance in China?
Sandostatin LAR® is the commercial brand name of Octreotide Acetate Microspheres for Injection, developed by Novartis. It is a long-acting somatostatin analogue microsphere preparation. It inhibits the secretion of growth hormone, glucagon and insulin, relieves symptoms caused by hormone-secreting neuroendocrine tumors and suppresses tumor progression with monthly intramuscular administration.
Main Indications
Long-term control of symptoms associated with acromegaly in patients responsive to subcutaneous octreotide;
Symptom control and tumor growth inhibition for unresectable well-differentiated gastroenteropancreatic neuroendocrine tumors;
Prophylaxis and treatment of severe diarrhea and flushing related to carcinoid syndrome.
Clinical Research
Global multicenter long-term trials fully validated its sustained hormone suppression efficacy for neuroendocrine tumor and acromegaly patients;
Acromegaly registration trials confirmed stable reduction of growth hormone and IGF-1 levels with once-monthly intramuscular injection;
GEP-NET cohort observational studies demonstrated durable control of diarrhea, flushing and slowdown of tumor volume progression;
Dose-response comparative research identified optimal monthly dosing with balanced symptom relief and tolerability;
Long-term safety follow-up trials verified controllable gastrointestinal and gallbladder-related mild adverse reactions during chronic maintenance therapy.
Common Side Effects
Common mild adverse reactions: Abdominal pain, diarrhea, nausea, flatulence, injection site pain and gallstone formation;
Laboratory abnormalities: Rare transient mild elevation of liver transaminases and glucose fluctuation;
Severe but uncommon risks: Severe hypersensitivity, bradycardia, biliary obstruction and hypoglycemia crisis.
Approval Status in China
Sandostatin LAR® (specification 20mg per vial) obtained marketing approval in China in 2000. It is an intramuscular injectable prescription anti-neuroendocrine tumor drug included in China’s Category B medical insurance catalogue.
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