Jiean Aluminium and Magnesium Aspirin Tablets

1. Indications and Usage
Therapeutic Indications: This medication is indicated for patients who require aspirin to inhibit platelet adhesion and aggregation but cannot tolerate the gastrointestinal side effects of aspirin alone.
Specific Conditions: It is used in the management of unstable angina, acute myocardial infarction, and ischemic cerebrovascular disorders.
2. Dosage and Administration
Dosage: Each tablet contains Aspirin 0.163 g, Magnesium Hydroxide 75 mg, and Aluminum Hydroxide 75 mg.
Administration: Oral administration. The specific dosage and frequency should be determined by the prescribing physician based on the clinical condition.
3. Mechanism of Action
Antithrombotic Effect: Aspirin inhibits the synthesis of thromboxane A2, thereby suppressing platelet adhesion and aggregation to prevent thrombus formation.
Gastroprotective Effect: The combination with aluminum and magnesium hydroxides mitigates the direct irritant effect of aspirin on the gastric mucosa, resulting in a lighter gastrointestinal profile compared to aspirin monotherapy.
Additional Effects: The formulation possesses antipyretic and analgesic properties.
4. Safety and Warnings
Contraindications: The drug is contraindicated in patients with active peptic ulcer disease, active bleeding, hemophilia, or thrombocytopenia.
Hypersensitivity: Use with caution in patients with a history of hypersensitivity to salicylates or non-steroidal anti-inflammatory drugs (NSAIDs).
Special Populations: Pregnant women (especially during the third trimester) and lactating women should use this medication with caution.
Precautions: Patients with a history of peptic ulcer disease should use this medication with caution.
5. Adverse Reactions and Clinical Research
Adverse Reactions: Adverse reactions are uncommon. Occasional gastrointestinal symptoms such as gastric discomfort, nausea, vomiting, and loss of appetite may occur. These symptoms typically resolve spontaneously after discontinuation of the drug.
Clinical Research: Comparative animal studies with aspirin monotherapy suggest that this formulation is absorbed more rapidly and has a milder effect on the gastric mucosa.
6. Drug Interactions
General Precaution: If the medication is used concurrently with other drugs, consultation with a physician or pharmacist is required prior to use.
7. Pharmaceutical Information
Active Ingredients: The active components are Aspirin (C9H8O4), Aluminum Hydroxide, and Magnesium Hydroxide.
Appearance: The tablets are white.
Storage: Store in a dry place; protect from light and keep sealed.