Wycakon-G Gefarnate Tablets

1. Indications and Usage
Peptic Ulcer Disease: Treatment of gastric and duodenal ulcers.
Gastritis: Management of acute and chronic gastritis.
Other Conditions: Used for jejunum ulcers, colitis, and gastric spasms.
2. Dosage and Administration
Adults:
Prevention: 50 mg three times daily.
Treatment: 100 mg three times daily (typical course is 1 month; severe cases may require 2-3 months).
Maintenance: Once symptoms improve, 50-100 mg three times daily.
Children: 50-100 mg three times daily.
Administration: Take as prescribed; do not discontinue early.
3. Mechanism of Action
Cellular Protection: Directly acts on gastric mucosal epithelial cells, enhancing their resistance to ulcerogenic factors.
Functional Regulation: Promotes ulcer healing, regulates gastrointestinal function, and modulates gastric acid secretion.
Pharmacokinetics: Readily absorbed after oral administration (60-70% absorption rate at 50 mg/kg), reaching peak plasma concentration within 6 hours. It is widely distributed in tissues, with the highest concentration in the gastrointestinal tract.
4. Safety and Warnings
Contraindications: Exercise caution in patients with contraindications to prostaglandin类药物 (e.g., patients with glaucoma).
Special Populations: Use with caution in pregnant and lactating women.
Monitoring: If severe adverse reactions occur, discontinue the medication immediately.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Occasional palpitations and gastrointestinal symptoms (e.g., dry mouth, nausea, constipation). These are generally mild and do not typically require discontinuation of the drug.
6. Drug Interactions
Spironolactone: May decrease the absorption of Gefarnate.
Amiloride: May delay the metabolism of Gefarnate and reduce its therapeutic efficacy.
7. Pharmaceutical Information
Active Ingredient: Gefarnate (Chemical name: (2E)-3,7-Dimethylocta-2,6-dien-1-yl(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate).
Molecular Formula: C27H44O2 (Molecular weight: 400.6).
Formulation: Tablets, typically 50 mg per tablet.
Storage: Store at room temperature in a dry place.