How much does REMODULIN (Treprostinil Injection) Cost& price without insurance in China?
REMODULIN® is the commercial brand name of Treprostinil Injection, developed by United Therapeutics Corporation. It is a stable prostacyclin analogue delivered via subcutaneous or intravenous infusion. It binds to prostacyclin receptors on vascular smooth muscle and platelets to dilate pulmonary and systemic blood vessels, inhibit platelet aggregation, reduce pulmonary vascular resistance and enhance cardiac output.
Main Indications
Treatment of pulmonary arterial hypertension (WHO Functional Class II-IV) to improve patients’ exercise capacity and relieve related clinical symptoms.
Clinical Research
Global multicenter pivotal clinical trials fully validated its therapeutic value for pulmonary arterial hypertension. Core efficacy trials confirmed continuous infusion therapy effectively prolongs exercise tolerance and alleviates dyspnea under daily activities. Long-term observational trials demonstrated sustained hemodynamic improvement and delayed disease progression for patients with progressive pulmonary hypertension. Tolerability comparative studies reflected that most mild adverse symptoms appear during dose titration and can be relieved with gradual dose adjustment. Safety follow-up research proved manageable overall adverse event spectrum during long-term chronic infusion treatment.
Common Side Effects
Common mild adverse reactions: Infusion site pain and erythema, facial flushing, headache, diarrhea, nausea, jaw pain and palpitations;
Laboratory abnormalities: Rare transient mild liver function fluctuation;
Severe but uncommon risks: Severe systemic hemorrhage, hypotension, pulmonary edema and hypersensitivity reactions.
Approval Status in China
REMODULIN® (specification 20mL:20mg, 1 vial per box) obtained marketing approval in China in 2021. It is an injectable prescription orphan drug for pulmonary arterial hypertension treatment included in China’s Category B medical insurance catalogue.
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