Seroxat® is the commercial brand name of Paroxetine Hydrochloride Enteric Coated Sustained-release Tablets, a selective serotonin reuptake inhibitor. It blocks serotonin reuptake at presynaptic nerve terminals to increase synaptic serotonin level and regulate mood.
Main Indications
For the treatment of major depressive disorder, panic disorder, social anxiety disorder and generalized anxiety disorder in adults.
Clinical Research
Clinical studies demonstrated that paroxetine CR achieves steady drug concentration with less fluctuation. It significantly improves core symptoms of depression and anxiety. Compared with immediate-release formulation, the enteric coated sustained-release tablet reduces early gastrointestinal adverse reactions while maintaining comparable therapeutic efficacy.
Common Side Effects
Nausea, somnolence, headache;
Other common reactions: dry mouth, sweating, sexual dysfunction. Rare serious adverse events include serotonin syndrome, suicidal ideation and withdrawal reactions upon abrupt discontinuation.
Approval Status in China
Original drug Seroxat® (Paroxetine Hydrochloride Enteric Coated Sustained-release Tablets) was officially approved for marketing in China in 2004, with the specification of 25mg per tablet. It is currently a prescription drug.
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