Aricept® is the commercial brand name of Donepezil Hydrochloride Tablets, an orally active reversible acetylcholinesterase inhibitor developed by Eisai. It elevates cerebral acetylcholine level to improve cognitive function in dementia patients. Main IndicationsSymptomatic treatment for mild to moderate Alzheimer’s disease.…
Leqembi® is the commercial brand name of Lecanemab Injection, a humanized monoclonal antibody jointly developed by Eisai and Biogen. It targets soluble aggregated amyloid-beta in the brain to clear cerebral amyloid deposits and slow disease progression of Alzheimer’s disease. Main…
Azilect® is the commercial brand name of Rasagiline Mesylate Tablets, an orally active irreversible monoamine oxidase-B inhibitor developed by Teva. It elevates intracerebral dopamine concentration to improve motor symptoms of Parkinson’s disease. Main IndicationsMonotherapy for early Parkinson’s disease;Adjunctive treatment combined…
Quviviq® is the commercial brand name of Daridorexant Hydrochloride Tablets, an orally active dual orexin receptor antagonist manufactured by Simcere Pharmaceutical. It blocks orexin receptors in the central nervous system to inhibit wake-promoting signaling and improve sleep onset and maintenance.…
Lorbrena® is the commercial brand name of Lorlatinib Tablets, an orally active third-generation selective ALK/ROS1 tyrosine kinase inhibitor developed by Pfizer. It potently inhibits mutated ALK kinase to block downstream oncogenic signaling and suppress tumor proliferation, including multiple crizotinib-resistant ALK…
Alunbrig® is the commercial brand name of Brigatinib Tablets, an orally active dual ALK/EGFR tyrosine kinase inhibitor developed by Takeda Pharmaceutical. It blocks abnormal ALK-driven downstream signaling cascade to suppress proliferation of ALK-rearranged tumor cells. Main IndicationsTreatment for adult patients…
Zelboraf® is the commercial brand name of Vemurafenib Tablets, an orally active BRAF serine/threonine kinase inhibitor developed by Roche. It selectively inhibits mutant BRAF V600 kinase to block abnormal MAPK signaling pathway and restrain proliferation of BRAF V600-mutated tumor cells.…
Tarceva® is the commercial brand name of Erlotinib Hydrochloride Tablets, an orally active reversible EGFR tyrosine kinase inhibitor developed by Roche. It selectively blocks epidermal growth factor receptor kinase to inhibit downstream tumor cell proliferation signaling. Main IndicationsFirst-line maintenance or…
Vizimpro® is the commercial brand name of Dacomitinib Tablets, an orally active irreversible pan-EGFR tyrosine kinase inhibitor developed by Pfizer. It irreversibly inhibits EGFR, HER2 and HER4 kinase activity to block downstream oncogenic signaling and suppress non-small cell lung cancer…
Giotrif® is the commercial brand name of Afatinib Dimaleate Tablets, an orally active irreversible EGFR/HER family tyrosine kinase inhibitor developed by Boehringer Ingelheim. It covalently binds to EGFR, HER2 and HER4 kinase domains to block downstream tumor proliferation signaling pathway.…