Lokelma® (Chinese brand name: Libeizhuo®) is the commercial brand name of Sodium Zirconium Cyclosilicate Powder, an inorganic zirconium silicate selective potassium binder developed by AstraZeneca. It works by selectively capturing potassium ions in the gastrointestinal tract and excreting bound potassium through feces to rapidly and sustainably lower serum potassium levels for patients with hyperkalemia.
Main Indications
Treatment of acute hyperkalemia in adult patients;
Long-term maintenance therapy to prevent recurrent hyperkalemia in adult patients with chronic kidney disease and heart failure.
Clinical Research
Global multicenter phase III pivotal trials demonstrated that sodium zirconium cyclosilicate achieves rapid serum potassium reduction within 1 hour after oral administration and maintains stable potassium control for long-term continuous administration without affecting calcium, magnesium and other electrolyte balance;
Registration clinical trials enrolling Chinese patients with renal hyperkalemia confirmed fast onset of potassium-lowering effect and consistent efficacy and safety outcomes compared with global study populations;
Real-world clinical research in Chinese nephrology centers verified its good compatibility with renin-angiotensin-aldosterone system inhibitors, enabling sustained use of cardiorenal protective drugs for high-risk patients.
Common Side Effects
Severe adverse reactions: Rare intestinal obstruction, severe hypersensitivity reaction;
Common mild adverse reactions: Nausea, vomiting, constipation, diarrhea, flatulence, gastrointestinal discomfort.
Approval Status in China
Lokelma® (Sodium Zirconium Cyclosilicate Powder, specification: 5g per sachet, 3 sachets per box, AstraZeneca original imported drug) was approved for marketing in China in 2019. It is a prescription oral potassium-lowering powder for emergency correction and long-term management of hyperkalemia.
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