Atozet® is the commercial brand name of Ezetimibe and Atorvastatin Calcium Tablets (II), an oral fixed‑combination product developed by Organon. Ezetimibe inhibits intestinal cholesterol absorption, while atorvastatin calcium suppresses hepatic cholesterol synthesis, jointly lowering blood lipid levels.
Main Indications
For the treatment of primary hypercholesterolemia in adult patients, as an adjunct to diet to reduce elevated total cholesterol, LDL‑cholesterol, triglycerides and raise HDL‑cholesterol.
Clinical Research
Clinical studies showed that the combination tablet provided greater LDL‑C reduction than atorvastatin monotherapy at the corresponding dose. It achieved target lipid goals in more patients and had a safety profile consistent with the individual components.
Common Side Effects
Headache, myalgia, fatigue, upper abdominal pain;
Other common reactions: diarrhea, nasopharyngitis. Rare serious adverse events include rhabdomyolysis, severe liver injury and hypersensitivity reactions.
Approval Status in China
Original drug Atozet® (Ezetimibe and Atorvastatin Calcium Tablets (II)) was officially approved for marketing in China in 2023, with the specification of 10mg/20mg, package containing 10 tablets. It is currently a prescription drug.
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