Delstrigo® is the commercial brand name of Doravirine, Lamivudine and Tenofovir Disoproxil Fumarate Tablets, developed by MSD. It is a once-daily oral fixed-dose triple antiretroviral combination tablet. Doravirine inhibits HIV reverse transcriptase; lamivudine and tenofovir disoproxil fumarate block viral DNA synthesis, jointly suppressing HIV-1 replication with low drug interaction risk.
Main Indications
Treatment of human immunodeficiency virus type 1 (HIV-1) infection in treatment-naive adult patients.
Clinical Research
Global multicenter phase III pivotal trials fully validated its sustained viral load suppression efficacy for untreated HIV-1 infected adults;
Head-to-head comparative trials confirmed lower incidence of central nervous system adverse reactions versus traditional NNRTI-based single-tablet regimens;
Long-term follow-up cohort studies demonstrated steady CD4+ T cell recovery and low virological failure rate under continuous daily administration;
Drug-drug interaction research verified minimal interference with common concomitant medications;
Chinese domestic registration trials confirmed stable antiviral efficacy and controllable safety profiles for local HIV patient populations.
Common Side Effects
Common mild adverse reactions: Dizziness, headache, fatigue, nausea, diarrhea and abnormal dreams;
Laboratory abnormalities: Rare transient mild elevation of liver transaminases and lipid level fluctuation;
Severe but uncommon risks: Severe hypersensitivity rash, lactic acidosis, renal tubular injury and hepatic decompensation in patients with chronic liver disease.
Approval Status in China
Original drug Delstrigo® (Chinese brand: Desizhuo) was officially approved for marketing in China in 2019, with the specification of 100mg Doravirine /300mg Lamivudine /300mg Tenofovir Disoproxil Fumarate per tablet, 30 tablets per box. It is currently a prescription anti-HIV drug included in China’s Category B medical insurance catalogue.
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