Fareston® is the commercial brand name of Toremifene Citrate Tablets, a selective estrogen receptor modulator (SERM) developed by Orion Corporation. It competitively binds to estrogen receptors on breast cancer cells, blocks estrogen-mediated tumor cell proliferation, and exerts anti-tumor endocrine therapeutic effects. This product is for oral administration only.
Main Indications
Treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or unknown hormone receptor status;
Adjuvant endocrine therapy for early estrogen receptor-positive breast cancer in postmenopausal female patients.
Clinical Research
Global multicenter Phase III pivotal trials proved that toremifene achieved equivalent anti-tumor efficacy compared with tamoxifen for first-line endocrine treatment of postmenopausal metastatic breast cancer, with a more favorable cardiovascular and uterine safety profile;
Domestic registration clinical trials enrolling Chinese postmenopausal breast cancer patients verified consistent tumor control efficacy and safety data matching global trial cohorts;
Long-term adjuvant therapy clinical studies confirmed durable disease-free survival benefit for early breast cancer patients, with lower risks of endometrial lesions and thromboembolic events relative to tamoxifen.
Common Side Effects
Frequent adverse reactions include hot flashes, sweating, vaginal discharge, vaginal bleeding, nausea, dizziness, edema, fatigue;
Infrequent serious adverse reactions involve endometrial thickening, venous thromboembolism, elevated liver enzymes, ocular abnormalities; most adverse reactions are mild to moderate and tolerable during long-term oral administration.
Approval Status in China
Fareston® (Toremifene Citrate Tablets, 60mg per tablet, 30 tablets per box) obtained marketing approval from the National Medical Products Administration (NMPA) at an early stage, being one of the classic oral endocrine therapeutic agents for postmenopausal breast cancer in China.
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