Novaferon® is the commercial brand name of Recombinant cytokine gene derived protein injection, a novel recombinant interferon protein developed by Genova Biotech. It binds to interferon receptors on cell surfaces, activating downstream signaling pathways to exert antiviral, anti-proliferative and immunoregulatory effects.
Main Indications
For the treatment of chronic hepatitis B in adult patients.
Clinical Research
Pivotal phase III clinical trials showed that Novaferon achieved sustained virological response in adult chronic hepatitis B patients. Compared with conventional interferon, it demonstrated favorable antiviral activity with a manageable safety profile, meeting the primary efficacy endpoint.
Common Side Effects
Flu-like symptoms: fever, chills, fatigue, myalgia and headache;
Other common reactions: decreased appetite, nausea, alopecia, transient liver function abnormalities. Rare serious adverse events include severe hypersensitivity, thyroid dysfunction and psychiatric symptoms.
Approval Status in China
Original drug Novaferon® (Recombinant Cytokine Gene Derived Protein Injection) was officially approved for marketing in China in 2019, with the specification of 10μg per 1.0ml vial. It is currently a prescription drug.
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