Prozac® is the original reference brand name, while the marketed domestic generic product in China is Bosiling®. It is a selective serotonin reuptake inhibitor (SSRI). It works by inhibiting serotonin reuptake in presynaptic neurons to increase synaptic serotonin concentration and exert antidepressant effects.
Main Indications
For the treatment of major depressive disorder, obsessive-compulsive disorder, and bulimia nervosa in adults; it can also be used for childhood and adolescent depression.
Clinical Research
Clinical trials demonstrated that fluoxetine significantly improves depressive symptoms and reduces obsessive-compulsive thoughts and compulsive behaviors. It shows sustained therapeutic effects after several weeks of continuous administration. The oral solution formulation is suitable for patients who cannot swallow solid tablets, with a generally tolerable safety profile.
Common Side Effects
Systemic reactions: insomnia, anxiety;
Common mild adverse reactions: nausea, dry mouth, headache, decreased appetite. Rare serious adverse events: suicidal ideation, serotonin syndrome.
Approval Status in China
This domestic generic drug, marketed under brand name Bosiling® (reference brand name Prozac®), was officially approved for marketing in China in 2024, with the specification of 5ml:20mg. It is currently a prescription psychiatric drug.
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