TRIMBOW® is the commercial brand name of Beclometasone Dipropionate, Formoterol Fumarate and Glycopyrrolate Inhalation Aerosol, a fixed-dose triple combination inhaled therapy containing inhaled corticosteroid, long-acting beta₂ agonist and long-acting muscarinic antagonist. It exerts anti-inflammatory and bronchodilatory effects to relieve airway constriction and improve respiratory symptoms.
Main Indications
Maintenance treatment of moderate to severe chronic obstructive pulmonary disease (COPD) in adult patients who are not adequately controlled on a combination of inhaled corticosteroid and long-acting beta₂ agonist.
Clinical Research
Global multicenter clinical trials demonstrated that this triple fixed combination therapy improves lung function, lowers the risk of moderate and severe COPD exacerbations, and alleviates dyspnea compared with dual bronchodilator or ICS/LABA treatment. Long-term observational studies verified persistent symptom control and a manageable safety profile.
Common Side Effects
Respiratory adverse reactions: nasopharyngitis, oral candidiasis, cough, dysphonia;
Other common adverse reactions: headache, muscle spasms, palpitations and dry mouth. Rare hypersensitivity reactions may be observed.
Approval Status in China
TRIMBOW® was officially approved for marketing in China in 2021. It is a prescription inhalation aerosol indicated for chronic obstructive pulmonary disease.
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