How much does XALKORI (Crizotinib Capsules) Cost& price without insurance in China?
XALKORI® is the commercial brand name of Crizotinib Capsules, a first-generation anaplastic lymphoma kinase (ALK) and c-MET/ROS1 tyrosine kinase inhibitor developed by Pfizer. It exerts anti-tumor activity by selectively inhibiting the kinase activity of ALK, ROS1 and c-MET, thereby blocking downstream signaling pathways and suppressing tumor cell proliferation and survival.
Main Indications
Treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic lymphoma kinase (ALK)-positive;
Treatment of locally advanced or metastatic NSCLC that is ROS1-positive.
Common Side Effects
Common adverse reactions: Visual disorder (flashes of light, blurred vision, photophobia), nausea, diarrhea, vomiting, edema, fatigue, decreased appetite, constipation, dizziness, and rash.
Laboratory abnormalities: Elevated transaminases, decreased white blood cell count, decreased neutrophil count, and decreased platelet count.
Severe but manageable risks: Hepatotoxicity, interstitial lung disease/pneumonitis, QT interval prolongation, bradycardia, and severe visual loss.
Approval Status in China
XALKORI® (Crizotinib Capsules, 250mg) was officially approved for marketing in China in January 2013. It is currently a prescription drug included in China’s Category B medical insurance.
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