How much does Invokana (Canagliflozin Tablets) Cost& price without insurance in China?
Invokana® is the commercial brand name of Canagliflozin Tablets, co-developed by Merck and Janssen. It is an oral sodium-glucose cotransporter 2 inhibitor. It inhibits glucose reabsorption in renal tubules to boost glycosuria excretion, lowering blood glucose independent of pancreatic beta cell function, while delivering extra benefits including weight loss and renal protection.
Main Indications
Improvement of glycemic control in adult patients with type 2 diabetes mellitus, applicable as monotherapy or combined with other hypoglycemic medicines;
Reduction of major cardiovascular adverse events and progression risk of kidney disease for type 2 diabetic patients with concomitant vascular and renal complications.
Clinical Research
Series of global multicenter clinical trials fully validated its multi-organ protective effects. Glycemic control trials confirmed sustained glucose-lowering efficacy relying on urinary glucose elimination pathway. Renal and cardiovascular outcome trials demonstrated obvious protective effects on kidney and cardiovascular system for high-risk diabetic populations. Tolerability research showed genitourinary discomfort as the primary mild adverse response with low hypoglycemia risk under monotherapy. Long-term observational trials verified stable lasting efficacy and manageable overall safety profile during prolonged administration.
Common Side Effects
Common mild adverse reactions: Genital fungal infection, urinary tract infection, polyuria, thirst and fatigue;
Laboratory abnormalities: Rare transient mild elevation of serum creatinine and ketone levels;
Severe but uncommon risks: Severe hypoglycemia (mostly combined with insulin or sulfonylureas), diabetic ketoacidosis, acute kidney injury and lower limb amputation risk.
Approval Status in China
Invokana® (specification 100mg, 10 tablets per box) obtained marketing approval in China in 2017. It is an oral prescription anti-diabetic drug covered by China’s Category B medical insurance catalogue.
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