Enstilar® is the commercial brand name of Calcipotriol and Betamethasone Dipropionate Foam (Chinese brand name: Enshida / 恩适达 ®), a compound topical foam preparation developed by LEO Pharma. Calcipotriol modulates keratinocyte proliferation and differentiation, while betamethasone dipropionate delivers potent anti-inflammatory, anti-pruritic and immunosuppressive effects. The aerosol foam formulation enhances skin penetration for rapid relief of psoriatic lesions. This product is for external skin use only.
Main Indications
Topical treatment for adult patients with plaque psoriasis.
Clinical Research
Global multicenter Phase III pivotal trials confirmed that once-daily foam treatment achieved significantly higher lesion clearance rate at Week 4 versus placebo, with rapid relief of erythema, scaling and pruritus for plaque psoriasis patients;
Phase III domestic registration trials recruiting Chinese plaque psoriasis subjects verified superior clinical efficacy of the foam compared with traditional ointment combination, with efficacy and safety data consistent with global multi-center clinical outcomes;
Long-term 52-week maintenance clinical trials demonstrated that intermittent maintenance treatment with the foam effectively prolonged disease remission and reduced psoriasis recurrence risk.
Common Side Effects
Common local adverse reactions include application site irritation, dryness, erythema, peeling and burning sensation;
Rare systemic adverse reactions include mild calcium metabolism abnormalities and hypothalamic-pituitary-adrenal (HPA) axis suppression after long-term large-area application; most cutaneous adverse events are mild-to-moderate and reversible after dose reduction or temporary drug pause.
Approval Status in China
Enstilar® (Chinese brand name: 恩适达 ®) was approved for marketing by the National Medical Products Administration (NMPA) on April 17, 2026. It is the first aerosol foam preparation for plaque psoriasis approved in China, imported and marketed by LEO Pharma.
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