Genvoya® is the international commercial brand name, and Jiefukang is its Chinese brand name. This fixed-dose four-component single-tablet antiretroviral regimen was developed by Gilead Sciences. Elvitegravir inhibits HIV integrase; cobicistat boosts elvitegravir exposure; emtricitabine and tenofovir alafenamide block viral reverse transcription. Combined, they suppress HIV replication comprehensively with once-daily oral administration.
Main Indications
Treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents weighing at least 35 kg with no prior antiretroviral treatment history.
Clinical Research
Global phase III registration trials fully validated its potent long-term HIV viral load suppression for treatment-naive HIV-1 infected patients;
Head-to-head comparative studies confirmed superior renal and bone safety profiles versus tenofovir disoproxil fumarate-based single-tablet regimens;
Long-term observational cohort trials demonstrated sustained CD4 cell recovery and low treatment failure rate during continuous oral therapy;
Dose stability research verified consistent plasma drug concentrations with once-daily single-tablet administration regardless of food intake;
Chinese domestic registration trials confirmed favorable antiviral efficacy and manageable safety spectrum for local HIV patient populations.
Common Side Effects
Common mild adverse reactions: Headache, nausea, diarrhea, fatigue, insomnia and abnormal dreams;
Laboratory abnormalities: Rare mild transient elevation of liver transaminases, slight lipid fluctuation;
Severe but uncommon risks: Severe hypersensitivity reaction, lactic acidosis, acute renal injury and hepatic decompensation in patients with underlying liver disease.
Approval Status in China
Original drug Genvoya® (Chinese brand: Jiefukang) was officially approved for marketing in China in 2018, with specifications of 150 mg Elvitegravir /150 mg Cobicistat /200 mg Emtricitabine /10 mg Tenofovir Alafenamide per tablet, 30 tablets per box. It is currently a prescription anti-HIV drug included in China’s Category B medical insurance catalogue.
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