How much does NESP (Darbepoetin Alfa Injection) Cost& price without insurance in China?
NESP® is the commercial brand name of Darbepoetin Alfa Injection, developed by Kyowa Kirin Co., Ltd. It is a long-acting recombinant human erythropoietin analogue. It binds to erythropoietin receptors on bone marrow erythroid progenitor cells to stimulate red blood cell proliferation and maturation, elevating hemoglobin levels for anemic patients with prolonged dosing intervals compared with short-acting erythropoietin.
Main Indications
Treatment of renal anemia in adult patients with chronic kidney disease, including patients on hemodialysis, peritoneal dialysis and non-dialysis chronic kidney disease patients;
Correction of chemotherapy-induced anemia in adult patients with solid tumors and malignant hematological tumors receiving myelosuppressive chemotherapy.
Clinical Research
Global multicenter pivotal trials fully validated its long-acting erythropoiesis-stimulating efficacy for anemic populations;
Chronic kidney disease registration trials confirmed stable hemoglobin maintenance with once-weekly or biweekly subcutaneous administration;
Chemotherapy-induced anemia observational studies demonstrated effective reduction of blood transfusion demand during tumor treatment cycles;
Dosing interval comparative research showed fewer injection times improve patient medication adherence versus short-acting erythropoietin;
Long-term follow-up trials verified controllable blood pressure fluctuation and overall manageable safety spectrum during chronic maintenance treatment.
Common Side Effects
Common mild adverse reactions: Headache, hypertension, arthralgia, fatigue and mild injection site pain;
Laboratory abnormalities: Rare transient elevated serum potassium levels;
Severe but uncommon risks: Severe hypertension crisis, pure red cell aplasia induced by anti-erythropoietin antibodies, thromboembolic events and hypersensitivity reactions.
Approval Status in China
NESP® (specification 40μg/0.5ml pre-filled syringe, 10 syringes per box) obtained marketing approval in China in 2006. It is a subcutaneous injectable prescription hematopoietic drug included in China’s Category B medical insurance catalogue.
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