Zexing® is the commercial brand name of Landiolol Hydrochloride for Injection, an ultra-short-acting β1-selective adrenoceptor blocker developed by Nanjing Hicin Pharmaceutical Co., Ltd. It competitively blocks cardiac β1 receptors to rapidly reduce heart rate and blood pressure, with fast onset and quick elimination.
Main Indications
For the treatment of tachyarrhythmia including atrial fibrillation, atrial flutter and sinus tachycardia in perioperative period;
For the control of ventricular rate in patients with atrial fibrillation or atrial flutter.
Clinical Research
A multicenter, randomized controlled Phase III trial in China verified that landiolol can rapidly and effectively control ventricular rate in perioperative tachyarrhythmia patients with high safety;
Clinical studies demonstrated its selective β1 blocking effect and short half-life, which enables quick recovery of heart rate after drug discontinuation;
Real-world clinical data confirmed good efficacy for critical patients with tachycardia and stable hemodynamic tolerance.
Common Side Effects
Severe but important risks: Severe hypotension, bradycardia, atrioventricular block and heart failure;
Common mild adverse reactions: Dizziness, nausea, vomiting, injection site reaction and cold sweats.
Approval Status in China
Original drug Zexing® (Landiolol Hydrochloride for Injection, specification:50mg per vial) was officially approved for marketing in China in 2020. It is currently a prescription cardiovascular drug.
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